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Researchers think that Cymbalta helps calm down these pain signals by increasing the level of two naturally occurring substances called serotonin and norepinephrineThese substanceswhich are found in the brain and other parts of the nervous systemcan affect mood and are believed to help control and suppress feelings of painCymbalta and other SNRIs block serotonin and norepinephrine from re-entering cellsand therefore increase the levels of these substancesThis process is thought to improve mood and relieve pain in patients with fibromyalgia.

Discontinuation-emergent symptoms have been reported when stopping CYMBALTAThe most commonly reported symptoms following discontinuation of CYMBALTA in pediatric clinical trials have included headachedizzinessinsomniaand abdominal painsee WARNINGS AND PRECAUTIONS and Adverse Reactions Reported As Reasons For Discontinuation Of Treatment In Adult Placebo-Controlled Trials

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